Yes, thyroid disease can affect mood. Common thyroid disease symptoms that affect mood include anxiety or depression. Rapid changes in thyroid hormone levels, in particular, can unsettle your emotions. With hyperthyroidism especially, rapid and effective control of the thyroid levels is essential to stabilise the mood, and it is important to make sure that the thyroid levels remain stable. Treatment: There are lots of people who can help: 1.talk to your doctor 2.ask to see a specialist with experience in dealing with thyroid disorders 3.confide in a family member or close friend who may be able to help you through this difficult time. Don’t feel awkward or embarrassed about talking to your doctor about the psychological symptoms associated with your thyroid disorder.